Debenhams is to reopen three stores in Northern Ireland and will resume trading at 50 sites in England on June 15.
The department stores chain is implementing heightened safety measures such as screens at till points, social distancing procedures and protective equipment for staff.
The firm went into administration for the second time in a year in April as the pandemic hit trading.
It agreed with landlords to keep 120 venues open, but 17 will remain permanently closed.
John Lewis Partnership will also restart 13 of its 50 department stores in mid-June, pacing all others based on the performance of the first ones.